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                                        CHEMICAL IDENTIFICATION
 
  RTECS NUMBER :
 
  LT7000000
  
 
  CHEMICAL NAME :
 
  2-Furaldehyde
  
 
  CAS REGISTRY NUMBER :
 
  98-01-1
  
 
  BEILSTEIN REFERENCE NO. :
 
  0105755
  
 
  LAST UPDATED :
 
  199801
  
 
  DATA ITEMS CITED :
 
  88
  
 
  MOLECULAR FORMULA :
 
  C5-H4-O2
  
 
  MOLECULAR WEIGHT :
 
  96.09
  
 
  WISWESSER LINE NOTATION :
 
  T5OJ BVH
  HEALTH HAZARD DATAACUTE TOXICITY DATA
 
  TYPE OF TEST :
 
  Standard Draize test
  
 
  ROUTE OF EXPOSURE :
 
  Administration onto the skin
  
 
  SPECIES OBSERVED :
 
  Rodent - rabbit
  
 
  TYPE OF TEST :
 
  Standard Draize test
  
 
  ROUTE OF EXPOSURE :
 
  Administration onto the skin
  
 
  SPECIES OBSERVED :
 
  Rodent - rabbit
  
 
  TYPE OF TEST :
 
  Standard Draize test
  
 
  ROUTE OF EXPOSURE :
 
  Administration into the eye
  
 
  SPECIES OBSERVED :
 
  Rodent - rabbit
  
 
  TYPE OF TEST :
 
  TCLo - Lowest published toxic concentration
  
 
  ROUTE OF EXPOSURE :
 
  Inhalation
  
 
  SPECIES OBSERVED :
 
  Human
  
 
  DOSE/DURATION :
 
  310 ug/m3
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  65 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LC50 - Lethal concentration, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Inhalation
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  175 ppm/6H
  
 
  TOXIC EFFECTS :
 
  Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Intraperitoneal
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  20 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Subcutaneous
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  148 mg/kg
  
 
  TOXIC EFFECTS :
 
  Behavioral - convulsions or effect on seizure threshold
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  400 mg/kg
  
 
  TOXIC EFFECTS :
 
  Tumorigenic - active as anti-cancer agent
  
 
  TYPE OF TEST :
 
  LCLo - Lowest published lethal concentration
  
 
  ROUTE OF EXPOSURE :
 
  Inhalation
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  370 ppm/6H
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Intraperitoneal
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  102 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Subcutaneous
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  119 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Intravenous
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  152 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Mammal - dog
  
 
  DOSE/DURATION :
 
  950 mg/kg
  
 
  TOXIC EFFECTS :
 
  Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - nausea or vomiting
  
 
  TYPE OF TEST :
 
  LC50 - Lethal concentration, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Inhalation
  
 
  SPECIES OBSERVED :
 
  Mammal - dog
  
 
  DOSE/DURATION :
 
  370 ppm/6H
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Subcutaneous
  
 
  SPECIES OBSERVED :
 
  Mammal - dog
  
 
  DOSE/DURATION :
 
  214 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Intravenous
  
 
  SPECIES OBSERVED :
 
  Mammal - dog
  
 
  DOSE/DURATION :
 
  250 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LDLo - Lowest published lethal dose
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - rabbit
  
 
  DOSE/DURATION :
 
  800 mg/kg
  
 
  TOXIC EFFECTS :
 
  Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - respiratory stimulation
  
 
  TYPE OF TEST :
 
  LDLo - Lowest published lethal dose
  
 
  ROUTE OF EXPOSURE :
 
  Administration onto the skin
  
 
  SPECIES OBSERVED :
 
  Rodent - rabbit
  
 
  DOSE/DURATION :
 
  620 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LDLo - Lowest published lethal dose
  
 
  ROUTE OF EXPOSURE :
 
  Subcutaneous
  
 
  SPECIES OBSERVED :
 
  Rodent - rabbit
  
 
  DOSE/DURATION :
 
  500 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Intramuscular
  
 
  SPECIES OBSERVED :
 
  Rodent - rabbit
  
 
  DOSE/DURATION :
 
  78 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LD50 - Lethal dose, 50 percent kill
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - guinea pig
  
 
  DOSE/DURATION :
 
  541 mg/kg
  
 
  TOXIC EFFECTS :
 
  Liver - hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - hemorrhage
  
 
  TYPE OF TEST :
 
  LDLo - Lowest published lethal dose
  
 
  ROUTE OF EXPOSURE :
 
  Subcutaneous
  
 
  SPECIES OBSERVED :
 
  Rodent - guinea pig
  
 
  DOSE/DURATION :
 
  100 mg/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  LDLo - Lowest published lethal dose
  
 
  ROUTE OF EXPOSURE :
 
  Parenteral
  
 
  SPECIES OBSERVED :
 
  Amphibian - frog
  
 
  DOSE/DURATION :
 
  23 gm/kg
  
 
  TOXIC EFFECTS :
 
  Details of toxic effects not reported other than lethal dose value
  
 
  TYPE OF TEST :
 
  TDLo - Lowest published toxic dose
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  91 mg/kg/14D-I
  
 
  TOXIC EFFECTS :
 
  Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
  
 
  TYPE OF TEST :
 
  TCLo - Lowest published toxic concentration
  
 
  ROUTE OF EXPOSURE :
 
  Inhalation
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  200 mg/m3/5H/12W-I
  
 
  TOXIC EFFECTS :
 
  Autonomic Nervous System - sympathomimetic Endocrine - other changes
  
 
  TYPE OF TEST :
 
  TCLo - Lowest published toxic concentration
  
 
  ROUTE OF EXPOSURE :
 
  Inhalation
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  10140 ug/m3/24H/60D-C
  
 
  TOXIC EFFECTS :
 
  Behavioral - muscle contraction or spasticity Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death
  
 
  TYPE OF TEST :
 
  TCLo - Lowest published toxic concentration
  
 
  ROUTE OF EXPOSURE :
 
  Inhalation
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  500 mg/m3/4H/4W-I
  
 
  TOXIC EFFECTS :
 
  Kidney, Ureter, Bladder - changes in both tubules and glomeruli
  
 
  TYPE OF TEST :
 
  TDLo - Lowest published toxic dose
  
 
  ROUTE OF EXPOSURE :
 
  Subcutaneous
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  75 mg/kg/6W-I
  
 
  TOXIC EFFECTS :
 
  Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count
  
 
  TYPE OF TEST :
 
  TDLo - Lowest published toxic dose
  
 
  ROUTE OF EXPOSURE :
 
  Subcutaneous
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  33 mg/kg/13W-I
  
 
  TOXIC EFFECTS :
 
  Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - normocytic anemia Blood - leukopenia
  
 
  TYPE OF TEST :
 
  TDLo - Lowest published toxic dose
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  4800 mg/kg/16D-I
  
 
  TOXIC EFFECTS :
 
  Related to Chronic Data - death
  
 
  TYPE OF TEST :
 
  TDLo - Lowest published toxic dose
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  4875 mg/kg/13W-I
  
 
  TOXIC EFFECTS :
 
  Liver - changes in liver weight
  
 
  TYPE OF TEST :
 
  TDLo - Lowest published toxic dose
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - rat
  
 
  DOSE/DURATION :
 
  30900 mg/kg/2Y-C
  
 
  TOXIC EFFECTS :
 
  Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
  
 
  TYPE OF TEST :
 
  TDLo - Lowest published toxic dose
  
 
  ROUTE OF EXPOSURE :
 
  Oral
  
 
  SPECIES OBSERVED :
 
  Rodent - mouse
  
 
  DOSE/DURATION :
 
  90125 mg/kg/2Y-C
  
 
  TOXIC EFFECTS :
 
  Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
  
 
  TYPE OF TEST :
 
  Specific locus test
  
 
  TYPE OF TEST :
 
  Sex chromosome loss and nondisjunction
  
 
  TYPE OF TEST :
 
  Sex chromosome loss and nondisjunction
  
 
  TYPE OF TEST :
 
  Sex chromosome loss and nondisjunction
  
 
  TYPE OF TEST :
 
  Mutation test systems - not otherwise specified
  MUTATION DATA
 
  TYPE OF TEST :
 
  Sister chromatid exchange
  
 
  TEST SYSTEM :
 
  Rodent - hamster Ovary
  
 
  DOSE/DURATION :
 
  11700 ug/L
  
 
  REFERENCE :
 
  NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR,382,1990 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 7.9 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,409,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,409,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,409,1995 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 5 ppm (20 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,120,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (20 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (8 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 2 ppm (7.9 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 2 ppm (8 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-JAPAN:TWA 2.5 ppm (9.8 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (8 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-RUSSIA:TWA 2.5 ppm;STEL 10 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (8 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (8 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 34120 No. of Facilities: 333 (estimated) No. of Industries: 11 No. of Occupations: 30 No. of Employees: 5904 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 34120 No. of Facilities: 6447 (estimated) No. of Industries: 79 No. of Occupations: 66 No. of Employees: 135914 (estimated) No. of Female Employees: 6706 (estimated)
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