Green and selective synthesis of N-substituted amides using water soluble porphyrazinato copper (II) catalyst

SSE Ghodsinia, B Akhlaghinia, E Safaei…

Index: Ghodsinia, Sara S. E.; Akhlaghinia, Batool; Safaei, Elham; Eshghi, Hossein Journal of the Brazilian Chemical Society, 2013 , vol. 24, # 6 p. 895 - 903

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Citation Number: 5

Abstract

ABSTRACT N, N', N'', N'''-Tetramethyl tetra-2, 3-pyridinoporphyrazinato copper (II) methyl sulfate ([Cu (2, 3-tmtppa)](MeSO 4) 4) efficiently catalyzed the direct conversion of nitriles to N-substituted amides. The one pot selective synthesis of the N-substituted amides from nitriles and primary amines was performed in refluxing H 2 O. The catalyst was recovered and reused at least four times, maintaining its efficiency.