The Journal of Organic Chemistry

Conformationally restricted arginine analogs

TR Webb, C Eigenbrot

Index: Webb, Thomas R.; Eigenbrot, Charles Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016

Full Text: HTML

Citation Number: 68

Abstract

We report the practical synthesis and structural characterization of a set of conformationally constrained protected arginine analogues. These enantiomerically pure analogues have the general structure 1 and are prepared in seven to eight steps from the commercially available isomers of 4-hydroxyproline. These analogues vary in side chain length and in relative and absolute stereochemistry and are suitable for the direct introduction into peptides. The ...