Nucleophilic Trifluoromethylation of Carbonyl Compounds: Trifluoroacetaldehyde Hydrate as a Trifluoromethyl Source

…, Z Zhang, F Wang, S Munoz, GA Olah

Index: Surya Prakash; Zhang, Zhe; Wang, Fang; Munoz, Socrates; Olah, George A. Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3300 - 3305

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Citation Number: 23

Abstract

A feasible nucleophilic trifluoromethylating protocol has been developed using trifluoroacetaldehyde hydrate as an atom-economical trifluoromethyl source. The reaction was found to be applicable to the nucleophilic trifluoromethylation of a broad spectrum of carbonyl compounds with satisfactory yields in general. DFT calculations have been performed to provide mechanistic insight into the present and related reactions employing ...