Novel hexakis (areneisonitrile) technetium (I) complexes as radioligands targeted to the multidrug resistance P-glycoprotein

…, LA Herman, D Piwnica-Worms

Index: Herman; Sharma; Kronauge; Barbarics; Piwnica- Worms Journal of Medicinal Chemistry, 1995 , vol. 38, # 15 p. 2955 - 2963

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Citation Number: 50

Abstract

Transport substrates and modulators of the human multidrug resistance (MDRI) P- glycoprotein (Pgp) are generally lipophilic cationic compounds, many with substituted aryl moieties. We sought to synthesize aromatic technetium-isonitrile complexes to enable functional detection in vivo of Pgp expression in tissues. A series of substituted aromatic isonitrile analogs were synthesized from their corresponding amines by reaction with ...