4-Aminoacetophenone

Modify Date: 2026-06-30 10:09:30

4-Aminoacetophenone structure	Common Name	4-Aminoacetophenone
	CAS Number	99-92-3	Molecular Weight	135.16
	Density	1.1±0.1 g/cm3	Boiling Point	294.8±13.0 °C at 760 mmHg
	Molecular Formula	C₈H₉NO	Melting Point	103-107 °C(lit.)
	MSDS	Chinese USA	Flash Point	132.1±19.8 °C
	Symbol	GHS07	Signal Word	Warning

Use of 4-Aminoacetophenone

1-(4-Aminophenyl)ethanone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	4-Aminoacetophenone
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	1-(4-Aminophenyl)ethanone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >> Others

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.1±0.1 g/cm3
Boiling Point	294.8±13.0 °C at 760 mmHg
Melting Point	103-107 °C(lit.)
Molecular Formula	C₈H₉NO
Molecular Weight	135.16
Flash Point	132.1±19.8 °C
Exact Mass	135.068420
PSA	43.09000
LogP	0.41
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.571

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

4-Aminoacetophenone MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM5500000

CHEMICAL NAME :: Acetophenone, p-amino-

CAS REGISTRY NUMBER :: 99-92-3

BEILSTEIN REFERENCE NO. :: 0471493

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C8-H9-N-O

MOLECULAR WEIGHT :: 135.18

WISWESSER LINE NOTATION :: ZR DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 381 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 14,465,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,31,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 596 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 14,465,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >70 mg/kg

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 80,31,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AM5500000
HS Code	29223900

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:100-19-6 4-Nitroacetophenone CAS#:13329-40-3 1-(4-Iodophenyl... CAS#:99-90-1 1-(4-Bromopheny... CAS#:20062-24-2 p-Azidoacetophenone
CAS#:38063-81-9 4-AMINOACETOPHE... CAS#:14235-81-5 4-Ethynylaniline CAS#:18179-86-7 4',4'''-Azobisa... CAS#:83810-18-8 4-(2-methyl-1,3...
CAS#:99-91-2 1-(4-Chlorophen...
DownStream 10
CAS#:107045-04-5 N-[(E)-1-(4-ami... CAS#:10517-47-2 Ethanone,1-[4-(... CAS#:109322-08-9 N-[(Z)-1-(4-ami... CAS#:111278-45-6 1-[4-(phenylsul...
CAS#:109702-67-2 1-[4-(prop-2-yn... CAS#:3673-53-8 4-(4-AMINO-PHEN... CAS#:5520-66-1 4-Diethylaminoa... CAS#:38283-38-4 n-(4-acetylphen...
CAS#:49647-20-3 Ethanone,1-(4-i... CAS#:54239-37-1 Cimaterol

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2922399090
Summary	2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

A simple, rapid and reliable liquid chromatography-mass spectrometry method for determination of methotrexate in human plasma and its application to therapeutic drug monitoring.

Biomed. Chromatogr. 29 , 1197-202, (2015)

A simple, rapid and reliable liquid chromatography-electrospray ionization tandem mass spectrometry method was established and validated for the determination of methotrexate in human plasma. After a ...

Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.

Pharm. Acta Helv. 73(4) , 215-8, (1998)

The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (H...

[Determination of p-aminoacetophenone and changes in its levels in a levorin producer depending on culture conditions].

Antibiotiki 26(8) , 566-70, (1981)

A method for spectrophotometric determination of p-aminoacetophenone (p-AAP) in the mycelium and fermentation broth filtrates of organisms producing polyenic macrolide antibiotics is described. The le...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Substrate activity at ADH105 (unknown origin) assessed as specific enzyme activity us...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5256043

Name: Competitive inhibition of Escherichia coli B H2-pteroate synthetase assessed as decre...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3280532

Name: Dissociation constant, pKa of the compound
Source: ChEMBL
Target: N/A
External Id: CHEMBL3280534

Name: Substrate activity at ADH101 (unknown origin) assessed as specific enzyme activity us...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5256042

Name: Substrate activity at ADH101 (unknown origin) assessed as specific enzyme activity us...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5256048

Name: Activation of mushroom tyrosinase using L-DOPA as substrate at 100 to 1000 umol/L pre...
Source: ChEMBL
Target: Polyphenol oxidase 2
External Id: CHEMBL3412102

Name: Substrate activity at ADH105 (unknown origin) assessed as specific enzyme activity us...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5256049

Total 7, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

1-(4-Aminophenyl)ethanone

MFCD00007896

p-Aminoacetylbenzene

p-Aminoacetophenone

p-acetylaniline

4-Acetylaniline

4-Amino acetophenone

EINECS 202-801-2

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the downstream products of 4-Aminoacetophenone?

A: Related downstream products(CAS) of 4-Aminoacetophenone: 107045-04-5;10517-47-2;109322-08-9;111278-45-6;109702-67-2;3673-53-8;5520-66-1;38283-38-4;49647-20-3;54239-37-1.

Q: What is the safety information for 4-Aminoacetophenone?

A: Safety information for 4-Aminoacetophenone: S26-S36.

Q: What is the polar surface area (PSA) of 4-Aminoacetophenone?

A: Polar surface area (PSA) of 4-Aminoacetophenone is 43.09000.

Q: What are the upstream materials of 4-Aminoacetophenone?

A: Related upstream materials(CAS) of 4-Aminoacetophenone: 100-19-6;13329-40-3;99-90-1;20062-24-2;38063-81-9;14235-81-5;18179-86-7;83810-18-8;99-91-2.

Q: What English synonyms does 4-Aminoacetophenone have?

A: English synonyms of 4-Aminoacetophenone: 1-(4-Aminophenyl)ethanone, MFCD00007896, p-Aminoacetylbenzene, p-Aminoacetophenone, p-acetylaniline, 4-Acetylaniline, 4-Amino acetophenone, EINECS 202-801-2.

Q: What is the CAS number of 4-Aminoacetophenone?

A: CAS number of 4-Aminoacetophenone is 99-92-3.

Q: What is the molecular formula of 4-Aminoacetophenone?

A: Molecular formula of 4-Aminoacetophenone is C8H9NO.

Q: What is the English name of 4-Aminoacetophenone?

A: The English name of 4-Aminoacetophenone is 4-Aminoacetophenone.

Q: What is the LogP of 4-Aminoacetophenone?

A: LogP of 4-Aminoacetophenone is 0.41.

Q: What is the molecular weight of 4-Aminoacetophenone?

A: Molecular weight of 4-Aminoacetophenone is 135.16.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4-Aminoacetophenone
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4'-Aminoacetophenone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Aminoacetophenone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 4-Aminoacetophenone
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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