Synlett

Domino Alkylation-Cyclization Reaction of Propargyl Bromides with Thioureas/Thiopyrimidinones: A New Facile Synthesis of 2-Aminothiazoles and 5H-Thiazolo [3, 2- …

D Castagnolo, M Pagano, M Bernardini, M Botta

Index: Castagnolo, Daniele; Pagano, Mafalda; Bernardini, Martina; Botta, Maurizio Synlett, 2009 , # 13 p. 2093 - 2096

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Citation Number: 9

Abstract

Abstract A new synthesis of 2-aminothiazoles and 5H-thiazolo [3, 2-a] pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thiopyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields.