Tetrahedron letters

Synthesis and antitumor activity of DNA binding cationic porphyrin–platinum (II) complexes

R Song, YS Kim, CO Lee, YS Sohn

Index: Song, Rita; Kim, Yeong-Sang; Lee, Chong Ock; Sohn, Youn Soo Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1537 - 1540

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Citation Number: 41

Abstract

A new series of DNA binding 5, 10, 15-tri (N-methyl-4-pyridiniumyl) porphyrin (TrisMPyP)- platinum (II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum (II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to cisplatin (T/C%, 184) against the leukemia L1210 cell line.