Tos-PEG2-OH

Modify Date: 2024-01-11 18:58:51

Tos-PEG2-OH Structure
Tos-PEG2-OH structure
Common Name Tos-PEG2-OH
CAS Number 118591-58-5 Molecular Weight 260.30700
Density N/A Boiling Point N/A
Molecular Formula C11H16O5S Melting Point N/A
MSDS USA Flash Point N/A

 Use of Tos-PEG2-OH


Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
Synonym More Synonyms

 Tos-PEG2-OH Biological Activity

Description Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C11H16O5S
Molecular Weight 260.30700
Exact Mass 260.07200
PSA 81.21000
LogP 1.79000

 Safety Information

Hazard Codes Xn
HS Code 2909499000

 Synthetic Route

~97%

Tos-PEG2-OH Structure

Tos-PEG2-OH

CAS#:118591-58-5

Literature: NATIONAL UNIVERSITY OF IRELAND, GALWAY Patent: US2011/217750 A1, 2011 ; Location in patent: Page/Page column 19 ;

~%

Tos-PEG2-OH Structure

Tos-PEG2-OH

CAS#:118591-58-5

Literature: Song, Rita; Kim, Yeong-Sang; Lee, Chong Ock; Sohn, Youn Soo Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1537 - 1540

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

2-(2-hydroxyethoxy)ethyl p-methylbenzenesulfonate
2-(2-hydroxyethoxy)ethyl 4-methyl benzenesulfonate
toluene-4-sulfonic acid 2-(2-hydroxyethoxy)ethyl ester
2-(2-{[(4-methylbenzene)sulfonyl]oxy}ethoxy)ethan-1-ol
diethylene glycol mono-p-toluenesulfonate
Ts(OCH2CH2)2OH
Ethanol,2-(2-hydroxyethoxy)-,1-(4-Methylbenzenesulfonate)
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