Tos-PEG2-OH

Modify Date: 2024-01-11 18:58:51

Use of Tos-PEG2-OH

Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
Synonym	More Synonyms

Description	Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Hazard Codes	Xn
HS Code	2909499000

Tosyl chloride

CAS#:98-59-9

Diethylene glycol

CAS#:111-46-6

~97%

Tos-PEG2-OH

CAS#:118591-58-5

Literature: NATIONAL UNIVERSITY OF IRELAND, GALWAY Patent: US2011/217750 A1, 2011 ; Location in patent: Page/Page column 19 ;

Methyl-PEG2-alcohol

CAS#:111-77-3

Tosyl chloride

CAS#:98-59-9

Tos-PEG2-OH

CAS#:118591-58-5

Literature: Song, Rita; Kim, Yeong-Sang; Lee, Chong Ock; Sohn, Youn Soo Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1537 - 1540

Precursor 3
CAS#:98-59-9 Tosyl chloride CAS#:111-46-6 Diethylene glycol CAS#:111-77-3 Methyl-PEG2-alcohol
DownStream 5
CAS#:139115-90-5 Azido-PEG2-alcohol CAS#:312610-28-9 3,4-bis[2-(2-hy... CAS#:142879-00-3 2-[2-(4-phenylm... CAS#:783-88-0 N-[2-(2-hydroxy...
CAS#:72358-83-9 N,N-bis[2-(2-hy...

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

2-(2-hydroxyethoxy)ethyl p-methylbenzenesulfonate

2-(2-hydroxyethoxy)ethyl 4-methyl benzenesulfonate

toluene-4-sulfonic acid 2-(2-hydroxyethoxy)ethyl ester

2-(2-{[(4-methylbenzene)sulfonyl]oxy}ethoxy)ethan-1-ol

diethylene glycol mono-p-toluenesulfonate

Ts(OCH2CH2)2OH

Ethanol,2-(2-hydroxyethoxy)-,1-(4-Methylbenzenesulfonate)

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