Tetrahedron

N-Alkylation of carbamates and amides with alcohols catalyzed by a Cp∗ Ir complex

K Fujita, A Komatsubara, R Yamaguchi

Index: Fujita, Ken-ichi; Komatsubara, Atsuo; Yamaguchi, Ryohei Tetrahedron, 2009 , vol. 65, # 18 p. 3624 - 3628

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Citation Number: 45

Abstract

New atom-economical catalytic systems consisting of [Cp∗ IrCl2] 2/NaOAc (Cp∗= pentamethylcyclopentadienyl) for the N-alkylation of carbamates and amides using alcohols as alkylating agents under solvent-free conditions have been developed. For example, the reaction of n-butyl carbamate with benzyl alcohol in the presence of [Cp∗ IrCl2] 2 (5.0 mol% Ir) and NaOAc (5.0 mol%) at 130° C under the absence of solvent gives n-butyl N- ...