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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Hydroxylated metabolites of loratadine: An example of conformational diastereomers due to atropisomerism

JJ Piwinski, JK Wong, TM Chan, MJ Green…

Index: Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

Full Text: HTML

Citation Number: 27

Abstract

... not reported. See: Lessen, N.; Perregaard, J. Acta Chem. Scand. 1983, B37, 335. (13) Williams, D. H.; Fleming, I. Spectroscopic Methods in Organic Chemistry, 2nd ed.; McGraw Hill: New York, 1973; pp 101-117. (14) (a ...

 Related Synthetic Route
Loratadine Impurity 2 Structure

31251-41-9

Loratadine Impu...

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

8-chloro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one Structure

117811-16-2

8-chloro-11H-be...

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

5-Methoxy-8-chloro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Structure

117811-21-9

5-Methoxy-8-chl...

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

5-Methoxy-8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ol Structure

117811-07-1

5-Methoxy-8-chl...

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

N/A Structure

117811-08-2

N/A

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinyl)-5,11-epoxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-5-ol Structure

126063-18-1

8-Chloro-6,11-d...

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

Ethyl 4-[8-Chloro-5-[(ethoxycarbonyl)oxy]-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxlate Structure

117811-10-6

Ethyl 4-[8-Chlo...

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

N/A Structure

126063-25-0

N/A

~%

5-Hydroxy Desloratadine Structure

117811-12-8

5-Hydroxy Deslo...

Loratadine Impurity 2 Structure

31251-41-9

Loratadine Impu...

~%

6-Hydroxy Desloratadine Structure

119410-05-8

6-Hydroxy Deslo...

8-chloro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one Structure

117811-16-2

8-chloro-11H-be...

~%

6-Hydroxy Desloratadine Structure

119410-05-8

6-Hydroxy Deslo...

8-Chloro-6-methoxy-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one Structure

117811-22-0

8-Chloro-6-meth...

~%

6-Hydroxy Desloratadine Structure

119410-05-8

6-Hydroxy Deslo...

N/A Structure

119410-11-6

N/A

~%

6-Hydroxy Desloratadine Structure

119410-05-8

6-Hydroxy Deslo...

N/A Structure

119410-09-2

N/A

~%

6-Hydroxy Desloratadine Structure

119410-05-8

6-Hydroxy Deslo...

Ethyl 4-[8-Chloro-6-[(ethoxycarbonyl)oxy]-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylate Structure

126063-19-2

Ethyl 4-[8-Chlo...

~%

6-Hydroxy Desloratadine Structure

119410-05-8

6-Hydroxy Deslo...

Ethyl 4-(8-Chloro-5,6-dihydro-6-oxo-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate Structure

126063-20-5

Ethyl 4-(8-Chlo...

~%

6-Hydroxy Desloratadine Structure

119410-05-8

6-Hydroxy Deslo...

Related Articles: More...
Hydroxylated metabolites of loratadine: An example of confor...

[Piwinski, John J.; Wong, Jesse K.; Chan, Tze-Ming; Green, Michael J.; Ganguly, Ashit K. Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3341 - 3350]
Hydroxylated metabolites of loratadine: An example of confor...

[Piwinski, John J.; Wong, Jesse K.; Chan, Tze-Ming; Green, Michael J.; Ganguly, Ashit K. Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3341 - 3350]

Detail Synthetic Route


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