Tetrahedron letters

Synthesis of 2-substituted-benzothiazoles by palladium-catalyzed intramolecular cyclization of o-bromophenylthioureas and o-bromophenylthioamides

C Benedı́, F Bravo, P Uriz, E Fernández, C Claver…

Index: Benedi, Carolina; Bravo, Fernando; Uriz, Pedro; Fernandez, Elena; Claver, Carmen; Castillon, Sergio Tetrahedron Letters, 2003 , vol. 44, # 32 p. 6073 - 6077

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Citation Number: 161

Abstract

Palladium-catalyzed arylnitrogen bond forming reactions 1 are highly useful for synthesizing arylamines and have found numerous applications in organic synthesis. Intramolecular palladium-catalyzed N-arylation reactions of aryl halides have been used to prepare indoles, 2 oxoindoles, 3 2-aryl-2H-indazoles, 4., and 1-aryl-1H-indazoles, 5 imidazoles, 6 oxazepines and thiazepines, 7 indolines, 8., and and other heterocycles 9., , , and (Scheme 1).