e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Palladium??Catalyzed Intramolecular Decarboxylative Coupling of Arene Carboxylic Acids/Esters with Aryl Bromides

Z Shen, Z Ni, S Mo, J Wang…

Index: Shen, Zengming; Ni, Zhenjie; Mo, Song; Wang, Jing; Zhu, Yamin Chemistry - A European Journal, 2012 , vol. 18, # 16 p. 4859 - 4865

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Citation Number: 37

Abstract

The transition-metal-catalyzed decarboxylation of aromatic carboxylic acids has emerged as an exciting strategy in organic synthesis because it enables the formation of aryl–metal intermediates by loss of CO2. This process can provide unconventional alternatives to perform various types of CÀ C and CÀheteroatom bond-forming reactions relative to typical organometallic reagents.[1] It is known that transition-metal-catalyzed cross-coupling ...

2-[acetyl-(2-bromobenzyl)amino]benzoic acid Structure

2-[acetyl-(2-br...

~56%

1-(6H-phenanthridin-5-yl)ethanone Structure

1-(6H-phenanthr...

N/A Structure

~%

1-(6H-phenanthridin-5-yl)ethanone Structure

1-(6H-phenanthr...

2-(2-bromobenzylamino)benzoic acid methyl ester Structure

2-(2-bromobenzy...

~%

1-(6H-phenanthridin-5-yl)ethanone Structure

1-(6H-phenanthr...

Methyl 2-aminobenzoate Structure

Methyl 2-aminob...

~%

1-(6H-phenanthridin-5-yl)ethanone Structure

1-(6H-phenanthr...

4-Bromobenzyl bromide Structure

4-Bromobenzyl b...

~%

1-(6H-phenanthridin-5-yl)ethanone Structure

1-(6H-phenanthr...

2-[(2-bromophenyl)methylamino]benzoic acid Structure

2-[(2-bromophen...

~88%

9-Methylcarbazole Structure

9-Methylcarbazole

2-(2-CHLORO-BENZYLOXY)-BENZOIC ACID Structure

2-(2-CHLORO-BEN...

~25%

6H-Dibenzo[b,d]pyran Structure

6H-Dibenzo[b,d]pyran

Methyl salicylate Structure

Methyl salicylate

~%

6H-Dibenzo[b,d]pyran Structure

6H-Dibenzo[b,d]pyran

2-Chlorotoluene Structure

2-Chlorotoluene

~%

6H-Dibenzo[b,d]pyran Structure

6H-Dibenzo[b,d]pyran

2-(2-chloro-benzyloxy)benzoic acid methyl ester Structure

2-(2-chloro-ben...

~%

6H-Dibenzo[b,d]pyran Structure

6H-Dibenzo[b,d]pyran

1-(Bromomethyl)-2-chlorobenzene Structure

1-(Bromomethyl)...

~%

6H-Dibenzo[b,d]pyran Structure

6H-Dibenzo[b,d]pyran

Phenyl salicylate Structure

Phenyl salicylate

4-Bromobenzyl bromide Structure

4-Bromobenzyl b...

~%

6H-Dibenzo[b,d]pyran Structure

6H-Dibenzo[b,d]pyran

N/A Structure

~61%

6(5H)-Phenanthridinone,5-methyl- Structure

6(5H)-Phenanthr...

N/A Structure

~%

6(5H)-Phenanthridinone,5-methyl- Structure

6(5H)-Phenanthr...

methyl 2-(2-bromobenzamido)benzoate Structure

methyl 2-(2-bro...

~%

6(5H)-Phenanthridinone,5-methyl- Structure

6(5H)-Phenanthr...

2-(2-chloro-benzyloxy)benzoic acid methyl ester Structure

2-(2-chloro-ben...

~85%

2-(2-CHLORO-BENZYLOXY)-BENZOIC ACID Structure

2-(2-CHLORO-BEN...

2-Chlorotoluene Structure

2-Chlorotoluene

~%

2-(2-CHLORO-BENZYLOXY)-BENZOIC ACID Structure

2-(2-CHLORO-BEN...

1-(Bromomethyl)-2-chlorobenzene Structure

1-(Bromomethyl)...

~%

2-(2-CHLORO-BENZYLOXY)-BENZOIC ACID Structure

2-(2-CHLORO-BEN...

methyl 2-(2-bromobenzamido)benzoate Structure

methyl 2-(2-bro...

~96%

2-[(2-bromobenzoyl)amino]benzoic acid Structure

2-[(2-bromobenz...

2-Bromobenzoic acid Structure

2-Bromobenzoic acid

~%

2-[(2-bromobenzoyl)amino]benzoic acid Structure

2-[(2-bromobenz...

Methyl 2-bromobenzoate Structure

Methyl 2-bromob...

~%

2-(2-bromoanilino)benzoic acid Structure

2-(2-bromoanili...

2-Bromoaniline Structure

~%

2-(2-bromoanilino)benzoic acid Structure

2-(2-bromoanili...