Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy

GE Martin, RJ Elgin Jr, JR Mathiasen…

Index: Martin; Elgin Jr.; Mathiasen; Davis; Kesslick; Baldy; Shank; DiStefano; Fedde; Scott Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1052 - 1056

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Citation Number: 70

Abstract

Generally, antipsychotic agents are dopamine receptor blocking agents that also block conditioned avoidance responding (CAR) in the rat. Recently, however, both (0- methoxypheny1) piperazine (OMPP, lh) and (m-chloropheny1) piperazine (MCPP, lo) have been reported to block conditioned avoidance responding in the rat although neither has dopamine receptor blocking properties. The present paper examines the behavioral and ...