Tetrahedron letters

Rapid and efficient synthesis of 1-arylpiperazines under microwave irradiation

HG Jaisinghani, BM Khadilkar

Index: Jaisinghani, Harsha G.; Khadilkar, Bhushan M. Tetrahedron Letters, 1997 , vol. 38, # 39 p. 6875 - 6876

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Citation Number: 27

Abstract

1-Arylpiperazines, finding wide applicability in pharmaceuticals were synthesized easily under microwave irradiation from bis (2-chloroethyl) amine hydrochloride and substituted anilines without any solvent. The reaction time was just 1–3 mins. 1-Arylpiperazines were synthesized in 53 to 73% yields. Potent serotonin ligands like Trifluoromethylphenylpiperazine (TFMPP) and 3-Chlorophenylpiperazine (mCPP) were ...