Synthesis of a small library of 2-phenoxy-1, 4-naphthoquinone and 2-phenoxy-1, 4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity

ML Bolognesi, F Lizzi, R Perozzo, R Brun…

Index: Bolognesi, Maria Laura; Lizzi, Federica; Perozzo, Remo; Brun, Reto; Cavalli, Andrea Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 7 p. 2272 - 2276

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Citation Number: 56

Abstract

Taking advantage of the structural features of natural products showing anti-trypanosomatid activity, we designed and synthesized a small library of 2-phenoxy-1, 4-naphthoquinone and 2-phenoxy-1, 4-anthraquinone derivatives. The library was obtained following a parallel approach and using readily available synthons. All the derivatives showed inhibitory activity toward either Trypanosoma or Leishmania species, with 8, 10, and 16 being the most ...