CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SJ3325000
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CHEMICAL NAME :
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Phenol
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CAS REGISTRY NUMBER :
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108-95-2
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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125
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MOLECULAR FORMULA :
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C6-H6-O
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MOLECULAR WEIGHT :
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94.12
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WISWESSER LINE NOTATION :
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QR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Open irritation test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
-
Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
-
Administration onto the skin
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SPECIES OBSERVED :
-
Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
-
Rodent - rabbit
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TYPE OF TEST :
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Rinsed with water
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - infant
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DOSE/DURATION :
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10 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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14 gm/kg
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TOXIC EFFECTS :
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Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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140 mg/kg
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TOXIC EFFECTS :
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Behavioral - hallucinations, distorted perceptions Skin and Appendages - sweating
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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317 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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316 mg/m3
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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669 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Kidney, Ureter, Bladder - hematuria Skin and Appendages - cutaneous sensitization, experimental (after topical exposure)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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127 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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460 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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270 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
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177 mg/m3
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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180 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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344 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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112 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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200 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
-
Mammal - cat
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DOSE/DURATION :
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80 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
-
Mammal - cat
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DOSE/DURATION :
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80 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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250 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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420 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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630 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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620 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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620 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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180 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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150 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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300 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
-
Rodent - guinea pig
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DOSE/DURATION :
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450 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Amphibian - frog
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DOSE/DURATION :
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75 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Amphibian - frog
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DOSE/DURATION :
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290 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Amphibian - frog
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DOSE/DURATION :
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290 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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5 mg/m3/4H/17W-I
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TOXIC EFFECTS :
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Liver - liver function tests impaired Endocrine - effect on menstrual cycle Blood - changes in leukocyte (WBC) count
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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100 ug/m3/24H/61D-C
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TOXIC EFFECTS :
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Behavioral - muscle contraction or spasticity Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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174 mg/kg/28D-C
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Blood - changes in erythrocyte (RBC) count Immunological Including Allergic - decreased immune response
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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16 gm/kg/40W-I
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TOXIC EFFECTS :
-
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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4000 mg/kg/24W-I
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TOXIC EFFECTS :
-
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
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DOSE :
-
300 mg/kg
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SEX/DURATION :
-
female 6-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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DOSE :
-
1200 mg/kg
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SEX/DURATION :
-
female 6-15 day(s) after conception
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TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
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DOSE :
-
600 mg/kg
-
SEX/DURATION :
-
female 12-14 day(s) after conception
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TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
2300 mg/kg
-
SEX/DURATION :
-
female 6-15 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
2600 mg/kg
-
SEX/DURATION :
-
female 6-15 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
4 gm/kg
-
SEX/DURATION :
-
female 6-15 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
2800 mg/kg
-
SEX/DURATION :
-
female 6-15 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
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TYPE OF TEST :
-
Cytogenetic analysis
-
TYPE OF TEST :
-
Unscheduled DNA synthesis
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
Micronucleus test
-
TYPE OF TEST :
-
DNA inhibition
MUTATION DATA
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TYPE OF TEST :
-
Mutation test systems - not otherwise specified
-
TEST SYSTEM :
-
Rodent - rabbit Bone marrow
-
REFERENCE :
-
AJIMD8 American Journal of Industrial Medicine. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 7,485,1985 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 19 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,263,1989 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,263,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,263,1989 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 TOXICOLOGY REVIEW JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,146,1949 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978 TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973 TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 5 ppm (19 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,203,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (19 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (19 mg/m3);STEL 10 ppm (38 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 4 mg/m3;STEL 8 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (10 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 ppm JAN 1993 OEL-RUSSIA:TWA 5 ppm;STEL 0.3 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 1 ppm (4 mg/m3);STEL 2 ppm (8 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (19 mg/m3);STEL 10 ppm (38 mg/m3);Skin JAN 1993 OEL-THAILAND:TWA 5 ppm (19 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (19 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (19 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENOL-air:10H TWA 5 ppm (Sk);CL 15.6 ppm/15M (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 55460 No. of Facilities: 23275 (estimated) No. of Industries: 185 No. of Occupations: 127 No. of Employees: 296662 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 55460 No. of Facilities: 31983 (estimated) No. of Industries: 229 No. of Occupations: 155 No. of Employees: 584372 (estimated) No. of Female Employees: 120977 (estimated)
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