Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity

H Kagechika, E Kawachi, Y Hashimoto…

Index: Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Himi, Toshiyuki; Shudo, Koichi Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2182 - 2192

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Citation Number: 245

Abstract

Two types of aromatic amides, terephthalic monoanilides and (ary1carboxamido) benzoic acids, have been shown to possess potent retinoidal activities and can be classified as retinoids. The structure-activity relationships of these amides are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60. In generic formula 4 (X= NHCO or CONH), the necessary factors to elicit the retinoidal activities are a ...

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