Transition metal-catalysed N-alkylation of amines by alcohols

R Grigg, TRB Mitchell, S Sutthivaiyakit…

Index: Grigg, R.; Mitchell, T. R. B.; Sutthivaiyakit, S.; Tongpenyai, N. Journal of the Chemical Society, Chemical Communications, 1981 , # 12 p. 611 - 612

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Citation Number: 121

Abstract

Primary and secondary alcohols effect alkylation of primary and secondary amines in the presence of rhodium, iridium, and ruthenium compounds at⩽ 100° C, whereby selective monoalkylation of primary amines can be achieved and heterocyclic rings can be constructed by both inter-and intra-molecular processes.