Pyrrolidine

Modify Date: 2026-06-30 12:05:15

Pyrrolidine Structure
Pyrrolidine structure
 Common Name Pyrrolidine
CAS Number 123-75-1 Molecular Weight 71.121
Density 0.8±0.1 g/cm3 Boiling Point 89.5±8.0 °C at 760 mmHg
Molecular Formula C4H9N Melting Point -63 °C
MSDS Chinese USA Flash Point 2.8±0.0 °C
Symbol GHS02 GHS05 GHS07
GHS02, GHS05, GHS07		 Signal Word Danger

Summary: Pyrrolidine, Chinese name: 四氢吡咯, CAS number: 123-75-1, molecular formula: C4H9N, molecular weight: 71.121. Appears as a transparent to yellow liquid, melting point: -63 °C, boiling point: 89.5±8.0 °C, density: 0.8±0.1 g/cm3. For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name pyrrolidine
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 0.8±0.1 g/cm3
Boiling Point 89.5±8.0 °C at 760 mmHg
Melting Point -63 °C
Molecular Formula C4H9N
Molecular Weight 71.121
Flash Point 2.8±0.0 °C
Exact Mass 71.073502
PSA 12.03000
LogP 0.37
Vapour density 2.45 (vs air)
Vapour Pressure 58.6±0.2 mmHg at 25°C
Index of Refraction 1.428
InChIKey RWRDLPDLKQPQOW-UHFFFAOYSA-N
SMILES C1CCNC1
Stability Stable; flammable. Incompatible with strong acids, strong oxidizing agents.

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9650000
CHEMICAL NAME :
Pyrrolidine
CAS REGISTRY NUMBER :
123-75-1
BEILSTEIN REFERENCE NO. :
0102395
LAST UPDATED :
199701
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C4-H9-N
MOLECULAR WEIGHT :
71.14
WISWESSER LINE NOTATION :
T5MTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Vascular - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(2),29,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 103,414,1964
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/m3/2H
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Vascular - other changes
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 18(2),29,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 88,82,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06769
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,104,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,104,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS02 GHS05 GHS07
GHS02, GHS05, GHS07
Signal Word Danger
Hazard Statements H225-H302 + H332-H314
Precautionary Statements P210-P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F:Flammable;C:Corrosive;
Risk Phrases R11;R20/21/22;R35
Safety Phrases S16-S26-S36/37/39-S45-S33
RIDADR UN 1922 3/PG 2
WGK Germany 2
RTECS UX9650000
Packaging Group II
Hazard Class 3
HS Code 2933990090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles52

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Prediction of the chromatographic retention of acid-base compounds in pH buffered methanol-water mobile phases in gradient mode by a simplified model.

J. Chromatogr. A. 1385 , 42-8, (2015)

Retention of ionizable analytes under gradient elution depends on the pH of the mobile phase, the pKa of the analyte and their evolution along the programmed gradient. In previous work, a model depend...

Electrospray ionization mass spectrometry of non-covalent complexes formed between N-alkylimidazolium-containing zwitterionic sulfonates and protonated bases.

Eur. J. Mass Spectrom. (Chichester, Eng.) 20(6) , 467-75, (2015)

This paper describes non-covalent complexes between zwitterionic 3-(1-alkyl-3N-imidazolio)- propane-1-sulfonates and different amines. Electrospray ionization (ESI) mass spectrometry and collision- in...

Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.

Mol. Inform. 34 , 709-714, (2016)

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Tetrahydro pyrrole
Pyrrolidine [UN1922] [Flammable liquid]
Tetramethyleneimine
Pyrrolidinepyrrolidine
Azolan
EINECS 204-648-7
1-Azacyclopentane
T5MTJ
Tetrahydropyrrole,Tetramethyleneimine
MFCD00005249
Pyrrolidine
Tetrahydropyrrole

 Pyrrolidine | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of pyrrolidine?
A: SMILES notation of pyrrolidine is C1CCNC1.
Q: What English synonyms does pyrrolidine have?
A: English synonyms of pyrrolidine: Tetrahydro pyrrole, Pyrrolidine [UN1922] [Flammable liquid], Tetramethyleneimine, Pyrrolidinepyrrolidine, Azolan, EINECS 204-648-7, 1-Azacyclopentane, T5MTJ, Tetrahydropyrrole,Tetramethyleneimine, MFCD00005249, Pyrrolidine, Tetrahydropyrrole.
Q: What is the CAS number of pyrrolidine?
A: CAS number of pyrrolidine is 123-75-1.
Q: What is the LogP of pyrrolidine?
A: LogP of pyrrolidine is 0.37.
Q: What is the molecular weight of pyrrolidine?
A: Molecular weight of pyrrolidine is 71.121.
Q: What are the upstream materials of pyrrolidine?
A: Related upstream materials(CAS) of pyrrolidine: 109-97-7;13325-10-5;616-45-5;110-63-4;56475-80-0;110-60-1;123477-57-6;5470-26-8;110-61-2.
Q: What is the safety information for pyrrolidine?
A: Safety information for pyrrolidine: S16-S26-S36/37/39-S45-S33.
Q: What is the English name of pyrrolidine?
A: The English name of pyrrolidine is pyrrolidine.
Q: What is the molecular formula of pyrrolidine?
A: Molecular formula of pyrrolidine is C4H9N.
Q: What are the downstream products of pyrrolidine?
A: Related downstream products(CAS) of pyrrolidine: 1064662-40-3;110829-36-2;109392-88-3;4383-25-9;2211-66-7;74-89-5;29897-82-3;3389-54-6;109028-59-3.

 Pyrrolidinefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides Pyrrolidine(CAS#:123-75-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Pyrrolidine are included as well.>> amp version: Pyrrolidine

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