An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc …

L Tan, P Zhou, C Chen, W Liu

Index: Tan, Liquan; Zhou, Peng; Chen, Cui; Liu, Weibing Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2681 - 2687

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Citation Number: 7

Abstract

Abstract A self-condensation cyclization reaction mediated by phosphorus pentoxide (P 2 O 5) and catalyzed by zinc bromide (ZnBr 2) is presented for the synthesis of polysubstituted 4- pyridones and 2-pyridones from β-keto amides. A variety of β-keto amides are used in this approach, and a wide range of functionalized 4-pyridones and 2-pyridones were obtained in good to excellent yields. When employing the N-aryl β-keto amides as the substrates in ...