Tetrahedron

Aryl alkynylation versus alkyne homocoupling: unprecedented selectivity switch in Cu, phosphine and solvent-free heterogeneous Pd-catalysed couplings

M Bandini, R Luque, V Budarin, DJ Macquarrie

Index: Bandini, Marco; Luque, Rafael; Budarin, Vitaly; Macquarrie, Duncan J. Tetrahedron, 2005 , vol. 61, # 41 p. 9860 - 9868

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Citation Number: 88

Abstract

Sonogashira reaction and oxidative dimerisation of terminal alkynes are among the most relevant and attractive C–C bond forming transformations in the metallo-catalysed cross- coupling scenario. Often, the homocoupling reactions of substituted acetylenic derivatives are concomitant to the Sonogashira pathway and time-consuming optimization procedures are required in order to reach satisfactory levels of selectivity. In this paper, the potential of ...