Science

Primary alcohols from terminal olefins: formal anti-Markovnikov hydration via triple relay catalysis

G Dong, P Teo, ZK Wickens, RH Grubbs

Index: Dong, Guangbin; Teo, Peili; Wickens, Zachary K.; Grubbs, Robert H. Science, 2011 , vol. 333, # 6049 p. 1609 - 1612

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Citation Number: 85

Abstract

Abstract Alcohol synthesis is critical to the chemical and pharmaceutical industries. The addition of water across olefins to form primary alcohols (anti-Markovnikov olefin hydration) would be a broadly useful reaction but has largely proven elusive; an indirect hydroboration/ oxidation sequence requiring stoichiometric borane and oxidant is currently the most practical methodology. Here, we report a more direct approach with the use of a triple ...