Helvetica Chimica Acta

One??Pot Synthesis of Pyrimidines via Cyclocondensation of β??Bromovinyl Aldehydes with Amidine Hydrochlorides

S Yan, Y Tang, F Yu, J Lin

Index: Yan, Shengjiao; Tang, Yajuan; Yu, Fuchao; Lin, Jun Helvetica Chimica Acta, 2011 , vol. 94, # 3 p. 487 - 490

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Citation Number: 10

Abstract

Results and Discussion. – Initially, an easily available starting material, β- bromovinyl aldehyde 1a, was reacted with 0.83 equiv. of 4-(trifluoromethyl)benzami- dine hydrochloride (2a) in 1,4-dioxane, catalyzed by Et3N and at reflux for 8h, successfully affording the pyrimidine 3a in good yield (85%; Scheme; Table, Entry 1). The product was identified by spectroscopic data and high-resolution mass spectrom- etry. Encouraged by this result, we explored the ...