Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases

C Hildebrand, D Sandoli, F Focher…

Index: Hildebrand, Catherine; Sandoli, Daniele; Focher, Federico; Gambino, Joseph; Ciarrocchi, Giovanni; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 203 - 206

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Citation Number: 32

Abstract

A series of N-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2. Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring such as m- trifluoromethyl (m-CF, PG, ICM= 0.1 WM) were the most potent inhibitors of both enzymes. Many derivatives were significantly more potent against the type 2 thymidine kinase, and ...