Quinones. 4. Novel eicosanoid antagonists: synthesis and pharmacological evaluation

…, K Kato, S Terao, Y Ashida, Z Terashita…

Index: Shiraishi; Kato; Terao; Ashida; Terashita; Kito Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2214 - 2221

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Citation Number: 48

Abstract

The synthesis of a series of w-phenyl-w-quinonylalkanoic acids 4a-u was carried out by the acid-catalyzed coupling reaction between hydroquinones 1 and a-substituted benzyl alcohols 2 or the y-lactone 3, followed by ferric chloride oxidation using an application of the Jurd and Wong method3 (Scheme I). The starting materials (2, 3) were prepared with the Friedel-Crafts reaction or the Grignard reaction: followed by sodium borohydride reduction ...