Organic letters

Switching regioselectivity in crossed acyloin condensations between aromatic aldehydes and acetaldehyde by altering n-heterocyclic carbene catalysts

MY Jin, SM Kim, H Han, DH Ryu, JW Yang

Index: Jin, Ming Yu; Kim, Sun Min; Han, Hogyu; Ryu, Do Hyun; Yang, Jung Woon Organic Letters, 2011 , vol. 13, # 5 p. 880 - 883

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Citation Number: 45

Abstract

Mixed acyloin skeletons are often found as the key structural motif for many natural products with interesting biological activities and synthetic therapeutics.(4) Despite the synthetic advantages of crossed acyloin condensations between two carbonyl compounds,(5) there are two drawbacks, the undesired self-condensations and the uncontrolled regiochemistry of crossed condensations. ... Given the importance of acetaldehdye as a simple nucleophile in ...