Enhanced aqueous solubility of long wavelength voltage-sensitive dyes by covalent attachment of polyethylene glycol

MJ Patrick, LA Ernst, AS Waggoner, D Thai…

Index: Patrick, Michael J.; Ernst, Lauren A.; Waggoner, Alan S.; Thai, Dung; Tai, Dean; Salama, Guy Organic and Biomolecular Chemistry, 2007 , vol. 5, # 20 p. 3347 - 3353

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Citation Number: 10

Abstract

Long wavelength voltage-sensitive dyes (VSDs) called Pittsburgh (PGH) dyes were recently synthesized by coupling various heterocyclic groups to a styryl-thiophene intermediate forming extended, partially rigid chromophores. Unlike most styryl VSDs, dyes with a sulfonic acid anchor directly attached to the chromophore showed no solvatochromic absorption shifts. The limited water solubility of many long wavelength VSDs requires the use of ...