Tetrahedron

The Synthesis of C 2-Symmetric and Axially Chiral Compounds for Recognition and Catalysis

J Clews, ADM Curtis, H Malkin

Index: Clews, John; Curtis, Anthony D.M.; Malkin, Hugh Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746

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Citation Number: 14

Abstract

Axially chiral amidines and guanidines, some possessing C2-symmetry, have been targeted as potential chiral catalysts for reactions of α, β-unsaturated carboxylic acids or esters. The key step in each synthesis required the coupling of two sterically demanding aromatic compounds to form atropisomeric biaryl species.