e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning

…, RE Banks, IM Young, RN Haszeldine

Index: Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N. Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547

Full Text: HTML

Citation Number: 10

Abstract

Abstract Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3-and-6-aldoxime, and 3- fluoropyridine-2-and-4-aldoxime, were synthesised. Attempts to obtain 3, 5, 6- trifluoropyridine-2, 4-bis (aldoxime) and-2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid ...

2-Amino-6-picoline Structure

2-Amino-6-picoline

~%

2-Fluoropyridine-6-carboxylic acid Structure

2-Fluoropyridin...

Isonicotinonitrile Structure

Isonicotinonitrile

~69%

2,3,5,6-Tetrachloro-4-pyridinecarbonitrile Structure

2,3,5,6-Tetrach...

3-Amino-4-methylpyridine Structure

3-Amino-4-methy...

~54%

3-Fluor-4-methylpyridin Structure

3-Fluor-4-methy...

Aminopicoline Structure

~%

3-Fluor-4-methylpyridin Structure

3-Fluor-4-methy...

tert-Butyl-dimethyl(phenoxy)silylperoxid Structure

tert-Butyl-dime...

~59%

2,3,5,6-Tetrafluoropyridine-4-carboxaldehyde Structure

2,3,5,6-Tetrafl...

2,3,5,6-Tetrafluoroisonicotinic acid Structure

2,3,5,6-Tetrafl...

Isonicotinonitrile Structure

Isonicotinonitrile

~%

2,3,5,6-Tetrafluoropyridine-4-carboxaldehyde Structure

2,3,5,6-Tetrafl...

Pentafluoropyridine Structure

Pentafluoropyridine

~%

2,3,5,6-Tetrafluoropyridine-4-carboxaldehyde Structure

2,3,5,6-Tetrafl...

2,3,5,6-Tetrachloro-4-pyridinecarbonitrile Structure

2,3,5,6-Tetrach...

~%

2,3,5,6-Tetrafluoropyridine-4-carboxaldehyde Structure

2,3,5,6-Tetrafl...

Pentafluoropyridine Structure

Pentafluoropyridine

~%

2,3,5,6-Tetrafluoropyridine-4-carboxaldehyde Structure

2,3,5,6-Tetrafl...

2,3,5,6-Tetrafluoroisonicotinic acid Structure

2,3,5,6-Tetrafl...

3-fluoro-2-styrylpyridine Structure

3-fluoro-2-styr...

~46%

3-fluoropicolinaldehyde Structure

3-fluoropicolin...

2-Amino-6-picoline Structure

2-Amino-6-picoline

~67%

6-Amino-3-nitro-2-picoline Structure

6-Amino-3-nitro...

2-AMino-3-nitro-6-Methylpyridine Structure

2-AMino-3-nitro...

2-Chloro-3-nitro-6-methylpyridine Structure

2-Chloro-3-nitr...

~66%

2-picolinamine Structure

1-Bromo-2,3,4,5,6-pentafluorobenzene Structure

1-Bromo-2,3,4,5...

~%

N-[(2,3,4,5,6-pentafluorophenyl)methylidene]hydroxylamine Structure

N-[(2,3,4,5,6-p...

2-Amino-6-picoline Structure

2-Amino-6-picoline

~0%

6-Amino-3-nitro-2-picoline Structure

6-Amino-3-nitro...

2-AMino-3-nitro-6-Methylpyridine Structure

2-AMino-3-nitro...

2-Fluoropyridine-6-carboxylic acid Structure

2-Fluoropyridin...

~72%

6-Fluoropyridine-2-carbonyl chloride Structure

6-Fluoropyridin...

1-Bromo-2,3,4,5,6-pentafluorobenzene Structure

1-Bromo-2,3,4,5...

Ethyl formate Structure

~38%

Pentafluorobenzaldehyde Structure

Pentafluorobenz...

2-Amino-6-picoline Structure

2-Amino-6-picoline

~%

2-Hydroxy-6-methyl-5-nitropyridine Structure

2-Hydroxy-6-met...

3-fluoro-4-styrylpyridine Structure

3-fluoro-4-styr...

~55%

3-Fluoroisonicotinaldehyde Structure

3-Fluoroisonico...

Aminopicoline Structure

~%

3-Fluoroisonicotinaldehyde Structure

3-Fluoroisonico...

3-Fluor-4-methylpyridin Structure

3-Fluor-4-methy...

~%

3-Fluoroisonicotinaldehyde Structure

3-Fluoroisonico...

3-Amino-4-methylpyridine Structure

3-Amino-4-methy...

~%

3-Fluoroisonicotinaldehyde Structure

3-Fluoroisonico...