InBr3??Catalyzed Deoxygenation of Carboxylic Acids with a Hydrosilane: Reductive Conversion of Aliphatic or Aromatic Carboxylic Acids to Primary Alcohols or …

N Sakai, K Kawana, R Ikeda, Y Nakaike…

Index: Sakai, Norio; Kawana, Keita; Ikeda, Reiko; Nakaike, Yumi; Konakahara, Takeo European Journal of Organic Chemistry, 2011 , # 17 p. 3178 - 3183

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Citation Number: 16

Abstract

Abstract A simple and practical procedure for the direct reduction of aliphatic carboxylic acids with a variety of functional groups to a primary alcohol using the mild reducing reagent tetramethyldisiloxane (TMDS), in the presence of a catalytic amount of InBr 3 has been developed. This simple reducing system, when used together with a hydrosilane, allows the preparation of the diphenylmethane derivative directly from an aromatic carboxylic acid ...