e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
The Journal of organic chemistry
Stereoelectronic effect on one-electron reductive release of 5-fluorouracil from 5-fluoro-1-(2'-oxocycloalkyl) uracils as a new class of radiation-activated antitumor …
A series of 5-fluoro-1-(2'-oxocycloalkyl) uracils (3-11) that are potentially novel radiation- activated prodrugs for the radiotherapy of hypoxic tumor cells have been synthesized to evaluate a relationship between the molecular structure and the reactivity of one-electron reductive release of antitumor 5-fluorouracil (1) in anoxic aqueous solution. All the compounds 3-11 bearing the 2'-oxo group were one-electron reduced by hydrated ...
