Synlett

Copper-Catalyzed Tandem Reaction of 2-Haloaniline Derivatives with Tetraalkylthiuram Disulfides: Selective Synthesis of 2-Aminobenzothiazoles

SS Pi, XG Zhang, RY Tang, JH Li

Index: Pi, Sha-Sha; Zhang, Xing-Guo; Tang, Ri-Yuan; Li, Jin-Heng Synlett, 2009 , # 18 p. 3032 - 3036

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Abstract

Abstract A simple and efficient protocol for the synthesis of 2-aminobenzothiazoles by copper-catalyzed tandem reaction has been developed. In the presence of CuBr and Cs 2 CO 3, a variety of 2-haloanilines underwent the reaction with tetramethylthiuram disulfide (TMTD) efficiently to afford the corresponding 2-aminobenzothiazoles in moderate to excellent yields. The present process allows the construction of 2-aminobenzothiazoles ...