Synthesis

N-Acylation of 5-substituted indoles with carboxylic acids via DCC coupling

JB Bremner, S Samosorn, JI Ambrus

Index: Bremner, John B.; Samosorn, Siritron; Ambrus, Joseph I. Synthesis, 2004 , # 16 p. 2653 - 2658

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Citation Number: 14

Abstract

Abstract A method for the N-acylation of 5-substituted indoles with carboxylic acids using DCC and DMAP is presented. High yields were obtained when an electron-withdrawing group was present at C-5, however the method was less effective with a C-5 electron- donating group.