Intramolecular Palladium-Catalyzed Alkane C− H Arylation from Aryl Chlorides

…, E Clot, K Fagnou, O Baudoin

Index: Chaumontet, Manon; Piccardi, Riccardo; Audic, Nicolas; Hitce, Julien; Peglion, Jean-Louis; Clot, Eric; Baudoin, Olivier Journal of the American Chemical Society, 2008 , vol. 130, # 45 p. 15157 - 15166

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Citation Number: 127

Abstract

The first examples of efficient and general palladium-catalyzed intramolecular C (sp3)− H arylation of (hetero) aryl chlorides, giving rise to a variety of valuable cyclobutarenes, indanes, indolines, dihydrobenzofurans, and indanones, are described. The use of aryl and heteroaryl chlorides significantly improves the scope of C (sp3)− H arylation by facilitating the preparation of reaction substrates. Careful optimization studies have shown that the ...