Phosphorylated ethyleneamide derivatives of uracils, their preparation and biological activity

…, TN Semenyuk, AI Potopal'skii, SV Ivasivka…

Index: Besyadetskaya, E. I.; Semenyuk, T. N.; Potopal'skii, A. I.; Ivasivka, S. V.; Savchuk, L. F.; et al. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 10 p. 744 - 750 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 10 p. 1185 - 1191

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Abstract

The alkylation of uracil and methyluracil with thiophosphamide or benzotef was carried out in an aqueous medium at pH i0. 0, and of nitrouracil in a neutral medium. The ethyleneimine rings of the reagent were opened, and the N-phosphorylated 2-aminoethyl residue entered into the 3-position of the uracil ring to form the corresponding derivatives. Thus, N, N', N"-tris [B-(3-uracil) ethyl] thiophosphoric acid triamine (Ia), N, N', N"-tris [~-(6-methyl-3-uracil)- ...