Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents

…, K Srivastava, SK Puri, PMS Chauhan

Index: Agarwal, Anu; Srivastava, Kumkum; Puri; Chauhan, Prem M.S. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6226 - 6232

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Citation Number: 42

Abstract

A series of 2, 4, 6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25–2μg/mL. These compounds are in vitro several fold more active than pyrimethamine.