Synthesis of 1-aryl-1H-indole derivatives by iodine-mediated cyclization of 2-(arylamino) styrene derivatives

K Kobayashi, K Miyamoto, T Yamase…

Index: Kobayashi, Kazuhiro; Miyamoto, Kazuna; Yamase, Tohru; Nakamura, Daizo; Morikawa, Osamu; Konishi, Hisatoshi Bulletin of the Chemical Society of Japan, 2006 , vol. 79, # 10 p. 1580 - 1584

Full Text: HTML

Citation Number: 8

Abstract

A convenient synthetic method for 1-aryl-1H-indole derivatives has been developed. 2- (Arylamino)-α-methylstyrene derivatives were treated with iodine in the presence of sodium hydrogencarbonate to give 1-aryl-3-methyl-1H-indole derivatives in fair to good yields. 3- Ethyl-2-methyl-1-phenyl-1H-indole and 3, 3′-dimethyl-1, 1′-(p-phenylene) diindole were also prepared from the respective 2-(phenylamino) styrene derivatives under the same ...