Molecular Nutrition & Food Research 2018-03-30

Metabolic Regulation of Methionine Restriction in Diabetes

Jie Yin; Wenkai Ren; Shuai Chen; Yuying Li; Hui Han; Jing Gao; Gang Liu; Xin Wu; Tiejun Li; Sung Woo Kim; Yulong Yin

Index: 10.1002/mnfr.201700951

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Abstract

Although the effects of dietary methionine restriction have been investigated in the physiology of aging and diseases related to oxidative stress, the relationship between methionine restriction and the development of metabolic disorders has not been explored extensively. This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway, and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes. Diets deficient in methionine may be a useful nutritional strategy in patients with diabetes.