e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

The Journal of organic chemistry

Oxidative arylation of isochroman

SJ Park, JR Price, MH Todd

Index: Gatta, Franco; Settimj, Guido Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1251 - 1254

Full Text: HTML

Citation Number: 57

Abstract

... The Journal of Organic ... J. Org. Chem. ... We undertook to find conditions for the still-unreported coupling between anisole and isochroman and to investigate the synthesis of various substituted derivatives (Scheme 1B). There are several reasons for investigating this chemistry. ...

1-(3,6-DIBROMO-CARBAZOL-9-YL)-3-PYRROLIDIN-1-YL-PROPAN-2-OL Structure

1-(3,6-DIBROMO-...

~81%

N-[1-(3-amino-1-benzofuran-2-yl)ethylidene]hydroxylamine Structure

N-[1-(3-amino-1...

1-(3,6-DIBROMO-CARBAZOL-9-YL)-3-PYRROLIDIN-1-YL-PROPAN-2-OL Structure

1-(3,6-DIBROMO-...

~%

5-methyl-3,4-dihydro-2H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-methyl-3,4-di...

ethyl N-(2-acetyl-1-benzofuran-3-yl)carbamate Structure

ethyl N-(2-acet...

~%

5-methyl-3,4-dihydro-2H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-methyl-3,4-di...

ethyl N-(2-acetyl-1-benzofuran-3-yl)-N-(cyanomethyl)carbamate Structure

ethyl N-(2-acet...

~%

5-methyl-3,4-dihydro-2H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-methyl-3,4-di...

2-acetyl-3-aminobenzofuran Structure

2-acetyl-3-amin...

~%

5-methyl-3,4-dihydro-2H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-methyl-3,4-di...

3-BROMO-4-CHLOROTOLUENE Structure

3-BROMO-4-CHLOR...

~%

5-phenyl-2,3-dihydro-1H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-phenyl-2,3-di...

ethyl N-(2-benzoyl-1-benzofuran-3-yl)carbamate Structure

ethyl N-(2-benz...

~%

5-phenyl-2,3-dihydro-1H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-phenyl-2,3-di...

ethyl N-(2-benzoyl-1-benzofuran-3-yl)-N-(cyanomethyl)carbamate Structure

ethyl N-(2-benz...

~%

5-phenyl-2,3-dihydro-1H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-phenyl-2,3-di...

3-amino-2-benzoylbenzofuran Structure

3-amino-2-benzo...

~%

5-phenyl-2,3-dihydro-1H-[1]benzofuro[3,2-e][1,4]diazepine Structure

5-phenyl-2,3-di...

3-BROMO-4-CHLOROTOLUENE Structure

3-BROMO-4-CHLOR...

~39%

N-[(3-amino-1-benzofuran-2-yl)-phenylmethylidene]hydroxylamine Structure

N-[(3-amino-1-b...

N-[1-(3-amino-1-benzofuran-2-yl)ethylidene]hydroxylamine Structure

N-[1-(3-amino-1...

Chloroacetyl chloride Structure

Chloroacetyl ch...

~54%

2-chloro-N-[2-[1-(hydroxyamino)ethylidene]-1-benzofuran-3-ylidene]acetamide Structure

2-chloro-N-[2-[...

3-chloroacetamido-2-(1-chloroacetoxyimino)ethylbenzofuran Structure

3-chloroacetami...

1-(3,6-DIBROMO-CARBAZOL-9-YL)-3-PYRROLIDIN-1-YL-PROPAN-2-OL Structure

1-(3,6-DIBROMO-...

~%

2-chloro-N-[2-[1-(hydroxyamino)ethylidene]-1-benzofuran-3-ylidene]acetamide Structure

2-chloro-N-[2-[...

N-[(3-amino-1-benzofuran-2-yl)-phenylmethylidene]hydroxylamine Structure

N-[(3-amino-1-b...

Chloroacetyl chloride Structure

Chloroacetyl ch...

~63%

2-chloro-N-[2-[(hydroxyamino)-phenylmethylidene]-1-benzofuran-3-ylidene]acetamide Structure

2-chloro-N-[2-[...

3-chloroacetamido-2-(α-chloroacetoxyimino)benzylbenzofuran Structure

3-chloroacetami...

3-BROMO-4-CHLOROTOLUENE Structure

3-BROMO-4-CHLOR...

~%

2-chloro-N-[2-[(hydroxyamino)-phenylmethylidene]-1-benzofuran-3-ylidene]acetamide Structure

2-chloro-N-[2-[...

1-(3,6-DIBROMO-CARBAZOL-9-YL)-3-PYRROLIDIN-1-YL-PROPAN-2-OL Structure

1-(3,6-DIBROMO-...

~%

4-hydroxy-5-methyl-3H-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

4-hydroxy-5-met...

N-[1-(3-amino-1-benzofuran-2-yl)ethylidene]hydroxylamine Structure

N-[1-(3-amino-1...

Chloroacetyl chloride Structure

Chloroacetyl ch...

~%

4-hydroxy-5-methyl-3H-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

4-hydroxy-5-met...

N-[(3-amino-1-benzofuran-2-yl)-phenylmethylidene]hydroxylamine Structure

N-[(3-amino-1-b...

Chloroacetyl chloride Structure

Chloroacetyl ch...

~58%

5-phenyl-3-hydroxy-1,3-dihydro-2H-benzofuro<3,2-e><1,4>diazepin-2-one Structure

5-phenyl-3-hydr...

4-hydroxy-5-phenyl-3H-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

4-hydroxy-5-phe...

4-hydroxy-5-methyl-3H-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

4-hydroxy-5-met...

~83%

5-methyl-3,4-dihydro-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

5-methyl-3,4-di...

1-(3,6-DIBROMO-CARBAZOL-9-YL)-3-PYRROLIDIN-1-YL-PROPAN-2-OL Structure

1-(3,6-DIBROMO-...

~%

5-methyl-3,4-dihydro-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

5-methyl-3,4-di...

N-[1-(3-amino-1-benzofuran-2-yl)ethylidene]hydroxylamine Structure

N-[1-(3-amino-1...

~%

5-methyl-3,4-dihydro-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

5-methyl-3,4-di...

1-(3,6-DIBROMO-CARBAZOL-9-YL)-3-PYRROLIDIN-1-YL-PROPAN-2-OL Structure

1-(3,6-DIBROMO-...

Ethyl chloroformate Structure

Ethyl chloroformate

~89%

ethyl N-(2-acetyl-1-benzofuran-3-yl)carbamate Structure

ethyl N-(2-acet...

4-hydroxy-5-phenyl-3H-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

4-hydroxy-5-phe...

~87%

5-phenyl-1,3-dihydro-[1]benzofuro[3,2-e][1,4]diazepin-2-one Structure

5-phenyl-1,3-di...

1-(3,6-DIBROMO-CARBAZOL-9-YL)-3-PYRROLIDIN-1-YL-PROPAN-2-OL Structure

1-(3,6-DIBROMO-...

~%

ethyl N-(2-acetyl-1-benzofuran-3-yl)-N-(cyanomethyl)carbamate Structure

ethyl N-(2-acet...

ethyl N-(2-acetyl-1-benzofuran-3-yl)carbamate Structure

ethyl N-(2-acet...

2-chloroacetonitrile Structure

2-chloroacetonitrile

~%

ethyl N-(2-acetyl-1-benzofuran-3-yl)-N-(cyanomethyl)carbamate Structure

ethyl N-(2-acet...

3-BROMO-4-CHLOROTOLUENE Structure

3-BROMO-4-CHLOR...

~%

ethyl N-(2-benzoyl-1-benzofuran-3-yl)-N-(cyanomethyl)carbamate Structure

ethyl N-(2-benz...

ethyl N-(2-benzoyl-1-benzofuran-3-yl)carbamate Structure

ethyl N-(2-benz...

2-chloroacetonitrile Structure

2-chloroacetonitrile

~%

ethyl N-(2-benzoyl-1-benzofuran-3-yl)-N-(cyanomethyl)carbamate Structure

ethyl N-(2-benz...