Enantioselective Lewis Acid-Catalyzed Mukaiyama-Michael Reactions of Acyclic Enones. Catalysis by a llo-Threonine-Derived Oxazaborolidinones

…, H Iwai, H Takatsuki, K Fujita, M Kubo…

Index: Booth, Paul M.; Fox, Christina, M. J.; Ley, Steve V. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 121 - 130

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Citation Number: 40

Abstract

... The Journal of Organic ... Table 1. OXB-Catalyzed Michael Reaction of Benzalacetone (4a) with Silyl Ketene Acetal 5a. ... a Method A: a mixture of 4a (0.5 M), 5a (1.5 equiv), and 1a,g in CH 2 Cl 2 was stirred for 1 h at −78 °C. Method B: To a solution of 5a (1.5 equiv, 0.75 M) and 1a in ...