Tetrahedron Letters 2018-04-07

Synthesis of benzyl halide derivatives of spirohydantoins via [2+2+2] cyclotrimerization reaction

Sanbasivarao Kotha, Gaddamedi Sreevani

Index: 10.1016/j.tetlet.2018.04.012

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Abstract

Generally, synthesis of hydantoin derivatives involve use of carbonyl compounds which in turn require multistep synthesis. Here, we report a new approach to assemble spirohydantoins via [2+2+2] cyclotrimerization reaction using commercially available, inexpensive hydantoin as a starting material.