Latest Articles of Tetrahedron Letters


A BODIPY-bearing pillar[5]arene for mimicking photosynthesis: multi-fluorophoric light harvesting system 10.1016/j.tetlet.2018.04.016 2018-04-11 Herein, we submitted to the original synthesis, characterization, energy transfer mechanism of the Bodipy-bearing pillar[5]arene Bodipy and its reactants by employing of infrared, 1H, 11B, 13C, 19F-NMRs, UV-vis, fluorescence spectroscopy, melting point appara...
A Highly Diastereoselective Chloride-Mediated Dynamic Kinetic Resolution at Phosphorus On-Route to a Key Intermediate in the Synthesis of GSK2248761A 10.1016/j.tetlet.2018.04.018 2018-04-11 A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available chiral auxi...
Efficient Suzuki-Miyaura mono-arylation of symmetrical diiodo(hetero)arenes 10.1016/j.tetlet.2018.04.015 2018-04-10 A reliable protocol for converting 1,4-diiodo-2,3,5,6-tetrafluorobenzene into 1-(hetero)aryl-4-iodo-2,3,5,6-tetrafluorobenzene derivatives has been lacking in the literature. We have identified optimal conditions to achieve this conversion in good yields and ...
Microwave promoted reaction of purin-6-yl magnesium halides with aldehydes in dichloromethane at 100 °C 10.1016/j.tetlet.2018.04.014 2018-04-10 Treatment of a dichloromethane solution of 9-benzyl or 9-phenyl 6-iodopurine with ethereal ethylmagnesium bromide at ambient temperature gives the corresponding purin-6-yl magnesium halides. Addition of an aldehyde followed by heating at 100 °C in a microwave...
Synthesis of benzyl halide derivatives of spirohydantoins via [2+2+2] cyclotrimerization reaction 10.1016/j.tetlet.2018.04.012 2018-04-07 Generally, synthesis of hydantoin derivatives involve use of carbonyl compounds which in turn require multistep synthesis. Here, we report a new approach to assemble spirohydantoins via [2+2+2] cyclotrimerization reaction using commercially available, inexpen...
Synthesis of functionalized iodoalkenes using a multicomponent reaction triggered by electrophilic iodination of alkenyldiazoacetates 10.1016/j.tetlet.2018.03.063 2018-04-04 Diazo compounds are frequently used as precursors of metal carbenoids and act as soft nucleophiles even without the use of metal catalysts. The resulting diazonium species may also be trapped by various nucleophiles. The introduction of an iodine functionalit...
Production of acetophenone C-glucosides using an engineered C-glycosyltransferase in Escherichia coli 10.1016/j.tetlet.2018.04.006 2018-04-04 Eight novel acetophenone mono- and bis-C-glucosides were obtained by whole cells harboring an engineered C-glycosyltransferase. Optimization of the fed-bath process improved the yield of 4a to 0.97 mg/mL with 95% conversion rate, which is 2.9-fold higher than...
A highly selective coumarin-based chemosensor for the sequential detection of Fe3+ and pyrophosphate and its application in living cell imaging 10.1016/j.tetlet.2018.04.007 2018-04-04 A new chemosensor based on coumarin FB has been designed and synthesized for the detection of Fe3+ and PPi. FB displayed a high affinity to Fe3+ in the presence of other competing cations. The resulting FB-Fe3+ complex displayed highly sensitivity to PPi via ...
Solvent- and environment-dependent fluorescence of modified nucleobases 10.1016/j.tetlet.2018.04.003 2018-04-03 Fluorescent nucleosides with modified nucleobases are useful tools for detecting nucleic acids and probing their structures and functions. Nucleobases are suitable for modification because 1) intrinsically light-absorbing nucleobases can be converted to fluor...
Recent Developments in the Synthesis of Prosophylline and Its Derivatives 10.1016/j.tetlet.2018.04.004 2018-04-03 Several synthetic efforts are reported towards the optically active (-)-prosophylline and (+)-prosophylline, and their derivatives. Interestingly and surprisingly, although only a few synthesis are reported for the parent molecules, there are more reports for...

A BODIPY-bearing pillar[5]arene for mimicking photosynthesis: multi-fluorophoric light harvesting system

10.1016/j.tetlet.2018.04.016

2018-04-11

Herein, we submitted to the original synthesis, characterization, energy transfer mechanism of the Bodipy-bearing pillar[5]arene Bodipy and its reactants by employing of infrared, 1H, 11B, 13C, 19F-NMRs, UV-vis, fluorescence spectroscopy, melting point appara...

A Highly Diastereoselective Chloride-Mediated Dynamic Kinetic Resolution at Phosphorus On-Route to a Key Intermediate in the Synthesis of GSK2248761A

10.1016/j.tetlet.2018.04.018

2018-04-11

A highly diastereoselective chloride-mediated dynamic kinetic resolution at phosphorus has been developed to access a key intermediate in the synthesis of GSK2248761A. This procedure utilises a soluble chloride source and a cheap readily available chiral auxi...

Efficient Suzuki-Miyaura mono-arylation of symmetrical diiodo(hetero)arenes

10.1016/j.tetlet.2018.04.015

2018-04-10

A reliable protocol for converting 1,4-diiodo-2,3,5,6-tetrafluorobenzene into 1-(hetero)aryl-4-iodo-2,3,5,6-tetrafluorobenzene derivatives has been lacking in the literature. We have identified optimal conditions to achieve this conversion in good yields and ...

Microwave promoted reaction of purin-6-yl magnesium halides with aldehydes in dichloromethane at 100 °C

10.1016/j.tetlet.2018.04.014

2018-04-10

Treatment of a dichloromethane solution of 9-benzyl or 9-phenyl 6-iodopurine with ethereal ethylmagnesium bromide at ambient temperature gives the corresponding purin-6-yl magnesium halides. Addition of an aldehyde followed by heating at 100 °C in a microwave...

Synthesis of benzyl halide derivatives of spirohydantoins via [2+2+2] cyclotrimerization reaction

10.1016/j.tetlet.2018.04.012

2018-04-07

Generally, synthesis of hydantoin derivatives involve use of carbonyl compounds which in turn require multistep synthesis. Here, we report a new approach to assemble spirohydantoins via [2+2+2] cyclotrimerization reaction using commercially available, inexpen...

Synthesis of functionalized iodoalkenes using a multicomponent reaction triggered by electrophilic iodination of alkenyldiazoacetates

10.1016/j.tetlet.2018.03.063

2018-04-04

Diazo compounds are frequently used as precursors of metal carbenoids and act as soft nucleophiles even without the use of metal catalysts. The resulting diazonium species may also be trapped by various nucleophiles. The introduction of an iodine functionalit...

Production of acetophenone C-glucosides using an engineered C-glycosyltransferase in Escherichia coli

10.1016/j.tetlet.2018.04.006

2018-04-04

Eight novel acetophenone mono- and bis-C-glucosides were obtained by whole cells harboring an engineered C-glycosyltransferase. Optimization of the fed-bath process improved the yield of 4a to 0.97 mg/mL with 95% conversion rate, which is 2.9-fold higher than...

A highly selective coumarin-based chemosensor for the sequential detection of Fe3+ and pyrophosphate and its application in living cell imaging

10.1016/j.tetlet.2018.04.007

2018-04-04

A new chemosensor based on coumarin FB has been designed and synthesized for the detection of Fe3+ and PPi. FB displayed a high affinity to Fe3+ in the presence of other competing cations. The resulting FB-Fe3+ complex displayed highly sensitivity to PPi via ...

Solvent- and environment-dependent fluorescence of modified nucleobases

10.1016/j.tetlet.2018.04.003

2018-04-03

Fluorescent nucleosides with modified nucleobases are useful tools for detecting nucleic acids and probing their structures and functions. Nucleobases are suitable for modification because 1) intrinsically light-absorbing nucleobases can be converted to fluor...

Recent Developments in the Synthesis of Prosophylline and Its Derivatives

10.1016/j.tetlet.2018.04.004

2018-04-03

Several synthetic efforts are reported towards the optically active (-)-prosophylline and (+)-prosophylline, and their derivatives. Interestingly and surprisingly, although only a few synthesis are reported for the parent molecules, there are more reports for...