Organic Chemistry Frontiers 2018-04-09

Enantioselective indium(I)-catalyzed [4 + 2] annulation of alkoxyallenes and β,γ-unsaturated α-keto esters

Sujia Li, Jian Lv, Sanzhong Luo

Index: 10.1039/C8QO00319J

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Abstract

An indium(I)–chiral phosphoric acid complex was found to catalyze the enantioselective [4 + 2] annulation reaction of β,γ-unsaturated α-keto esters with alkoxyallenes, affording cyclic O,O-acetals in good yields and with high regio- and stereo-selectivities.