The Journal of organic chemistry

Room temperature preparation of trifluoroethenylzinc reagent by metalation of the readily available halocarbon HFC-134a and an efficient, economically viable …

A Raghavanpillai, DJ Burton

Index: Raghavanpillai, Anilkumar; Burton, Donald J. Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7083 - 7091

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Citation Number: 35

Abstract

Trifluoroethenylzinc reagent [CF2 CFZnX] was generated from the readily available halocarbon HFC-134a by an in situ metalation-transmetalation procedure at temperatures near to room temperature (15-20° C). By systematic standardization of the metalation experiments by manipulation of solvent, cosolvent, temperature, zinc salt, and the base, the trifluoroethenylzinc reagent was produced in 73% yield at 20° C in THF medium. The ...

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