Palladium??Catalyzed Base??Free Suzuki–Miyaura Coupling Reactions of Fluorinated Alkenes and Arenes via a Palladium Fluoride Key Intermediate

M Ohashi, H Saijo, M Shibata…

Index: Ohashi, Masato; Saijo, Hiroki; Shibata, Mitsutoshi; Ogoshi, Sensuke European Journal of Organic Chemistry, 2013 , # 3 p. 443 - 447

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Citation Number: 24

Abstract

Abstract A new strategy for C–C bond formation with organoboronates through C–F activation of fluorinated alkenes and arenes was developed. In this Pd-catalyzed Suzuki– Miyaura-type cross-coupling reaction, neither a base for enhancing the reactivity of the organoboron reagents nor a Lewis acid for promoting C–F bond activation was required. A fluoropalladium intermediate played an essential role in this reaction. In addition, a Ni ( ...