Tetrahedron letters

Coupling reactions of aryl bromides with 1-alkynols catalysed by a tetraphosphine/palladium catalyst

M Feuerstein, H Doucet, M Santelli

Index: Feuerstein, Marie; Doucet, Henri; Santelli, Maurice Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1603 - 1606

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Citation Number: 28

Abstract

cis, cis, cis-1, 2, 3, 4-Tetrakis (diphenylphosphinomethyl) cyclopentane/[PdCl (C3H5)] 2 system catalyses efficiently the coupling reactions of aryl halides with a variety of alkynols such as propargyl alcohol, but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol. The catalyst can be used at low loading. Higher reaction rates were observed in the presence of but-1-yn-4-ol, pent-1-yn-5-ol or hex-1-yn-6-ol than with propargyl alcohol. The protection of the alcohol ...