Synthesis of 1, 2, 4-triazino [5, 6-b]-and imidazo [4, 5-b] quinoline derivatives

J Slouka, V Bekárek, K Nálepa…

Index: Slouka, Jan; Bekarek, Vojtech; Nalepa, Karel; Lycka, Antonin Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 11 p. 2628 - 2634

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Citation Number: 10

Abstract

Abstract o-Nitrophenylpyruvic acid thiosemicarbazone (I) has been cyclized to 2-thio-5-(o- nitrobenzyl)-6-azauracil (II) which has been transformed in 5-(o-nitrobenzyl)-6-azauracil (III) by both oxidation, and methylation and hydrolysis of the 3-methylmercapto-6-(o-nitrobenzyl)- 2, 5-dihydro-1, 2, 4-triazin-5-one (V) formed. Reduction of derivative III with iron (II) hydroxide and cyclization of the amino derivative IV formed gives 2, 3, 4, 10-tetrahydro-1, ...