Tetrahedron Letters

A microwave-assisted, propylphosphonic anhydride (T3P®) mediated one-pot Fischer indole synthesis

M Desroses, K Wieckowski, M Stevens, LR Odell

Index: Desroses, Matthieu; Wieckowski, Krzysztof; Stevens, Marc; Odell, Luke R. Tetrahedron Letters, 2011 , vol. 52, # 34 p. 4417 - 4420

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Citation Number: 45

Abstract

The indole nucleus is a versatile heterocyclic system, occurring in a variety of compounds with a broad spectrum of biological activities. 16 Consequently, indole and its myriad of derivatives continue to capture the attention of organic and medicinal chemists and a variety of well established methods are now available for their production. 17 Amongst these, the Fischer indole synthesis from ketones and arylhydrazines is the most widely employed synthetic procedure, ...