Tetrahedron letters

A mild and selective C-3 reductive alkylation of indoles

JE Appleton, KN Dack, AD Green, J Steele

Index: Appleton, Julie E.; Dack, Kevin N.; Green, Andrew D.; Steele, John Tetrahedron Letters, 1993 , vol. 34, # 9 p. 1529 - 1532

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Citation Number: 39

Abstract

Abstract In the presence of triethylsilane and trifluoroacetic acid, the reaction between indoles and aldehydes in dichloromethane at 0 C, results in good yields of C-3 reductively alkylated products. The transformation is most effective for the preparation of 3-(arylmethyl) indoles 6 from aromatic aldehydes.